NIH Funding to Identify Potential Pathways for Treatments

Dr. Roy is known for his success finding treatable pathways in Parkinson's, Alzheimers, and related diseases.

This ATG-13 study will help Simmaron’s team to develop a targeted pathway for treating neuroinflammation found in diseases like ME/CFS, POTS, and Long-Covid.

Our Early ATG-13 Findings

Last year, our groundbreaking publication on autophagy in ME/CFS showed a protein called ATG-13 is a player in brain inflammation. Our new NIH grant, which was very well received by reviewers, will further this investigation into whether ATG-13 can be a treatable pathway for ME/CFS.

‘Autophagy’ is the critical waste-removal process of the cell that we have recently shown to be dysfunctional in ME/CFS patients.

Normally, this protein is inside the cell where it initiates the cell’s critical “clean up” process called autophagy. Instead, ATG-13 in ME/CFS patients was roving free, small enough to permeate the vascular system. So small, in fact, that it was able to cross the blood brain barrier, where we found it setting off the microglia—the brain's immune cells.

We believe we have found a critical pathway involved in post-exertional malaise (PEM), the hallmark symptom of ME/CFS.

Let’s Change Everything about ME, LongCovid, and POTS Together!

We're aiming squarely at building the tools for drug discovery so ME, POTS and Long-Covid patients can finally have treatments. Thank you for supporting our team.